What is it about?
We compared the accuracy of the automated haematology analyser Sysmex XN‐3000 for schistocyte detection, to that of the microscopy approach. We found that Sysmex XN‐3000 can be used for qualitative measurement of schistocytosis, but should not be used as a quantitative tool for schistocyte counting. Improvements are needed before this analyser's schistocyte detection feature can be recommended for use in clinical practice.
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Why is it important?
The identification of schistocytes by microscopy need well‐trained personnel. This approach has limitations in clinical practice, including a lack of standardization and time‐consuming. We thought that the Sysmex XN‐3000 might be an appropriate tool for accurately determining schistocyte count. If so, this would obviate the need for experienced personnel to confirm the schistocytes and reduce the time to diagnosis and treatment for life-threatening diseases such as thrombotic thrombocytopenic purpura (TTP).
Perspectives
Writing this article helped me understand a lot about how to evaluate the accuracy of a diagnostic tool and statistics. Thank you very much for effective review and very useful comments from the editor and reviewers of Health Science Reports team.
Dr Chattree Hantaweepant
Siriraj Hospital Mahidol University
Read the Original
This page is a summary of: Comparison between optical microscopy and the Sysmex XN-3000 for schistocyte determination in patients suspected of having schistocytosis, Health Science Reports, November 2019, Wiley,
DOI: 10.1002/hsr2.138.
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