Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice: Public health impact

What is it about?

Hepatic fibrosis is emerging as a significant public health image in susceptible populations worldwide; however, healthcare financial resources should be strategically streamlined for timeline based translational cell biology research with relevant animal models of disease. Genetic architecture of diet-induced hepatic fibrosis in mice may be investigated with future design of replicative study protocols in human subjects with proven hepatic fibrosis so as to eventually design cost-effective predictive biomarkers in hepatic fibrosis management in specific disease subsets.

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Why is it important?

I, Dr. Saumya Pandey PH.D., have significant interest in the ever-expanding hepatology research field; the overall public health impact of my article is immense and the meticulously drafted article provides a crisp snapshot of hepatic fibrosis in mice models; sample size adequacy is advocated for drawing meaningful interpretation of complex data-sets in the animal model of disease. Future studies involving clinically confirmed liver fibrosis cases and age-matched, healthy controls may be designed by targeting metabolic/cell signaling pathways including molecular regulatory networks with inflammation/immune-related genes/proteins viz. high mobility group box 1 HMGB1, TGF-beta, Smad, Toll-like receptors, Wnt-Frizzled, Autophagy,etc. I would like to add that animal models and human subjects research should be ethically conducted so as to promote scientific integrity amongst scientists/physicians worldwide!

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