What is it about?
Chromatin remodeling protein can make chromatin in an "open" status for the access of transcriptional factors. We have shown for the first time that CHD1L is dynamically expressed during hepatocyte differentiation and can open chromatin for developmental transcriptional factors. Activation of CHD1L enables HCC cells with progenitor cell like properties and poor differentiation.
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Why is it important?
This study indicated that the chromatin remodeling protein are important in regulating the differentiation status of HCC tumor cell.
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This page is a summary of: CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors, Hepatology, March 2016, Wiley,
DOI: 10.1002/hep.28437.
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