Involvement of a cyclic adenosine monophosphate-dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate-binding cassette transporter g5/g8

What is it about?

In this article, we generate a novel in vivo kinetic analysis tht can monitor the intracellular trafficking of cholesterol transporter Abcg5/Abcg8 in living mouse liver and how hypernutrition affects the canalicular trafficking of these transporters. Our observations suggest that diet-induced lipid loading into liver accelerates the trafficking of Abcg5/Abcg8 to the bile canalicular membrane through cAMP signaling machinery.

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Why is it important?

We demonstrate, for the first time, that diet-induced nutritional change in liver can modulate the trafficking of canalicular transporters in vivo. The in vivo kinetic analysis provide a new approach for monitoring hepatic protein trafficking in liver. Numerous questions on the effect of pathological changes on the traffikcing of pathogenic factors in hepatocytes can thereby be addressed, providing new insight into how molecular machinery causes various liver disorders.