What is it about?

Cellular aging is responsible for epithelial thinning and relief from this mediates hyperplastic epithelium and malignant transformation in oral submucous fibrosis.

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Why is it important?

This article gives a novel mechanism for oral submucous fibrosis development through the aging of epithelial and connective tissue compartments. Inhibition of this process has the potential to restore epithelial homeostasis.

Perspectives

Targetting and destroying the aging cells might help in restoring the epithelial homeostasis and normal healing pattern in oral submucous fibrosis.

Professor Mohit Sharma
SGT Dental College Hospital & Research Institute

Read the Original

This page is a summary of: Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation, Head & Neck, July 2021, Wiley,
DOI: 10.1002/hed.26805.
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