What is it about?
Pain fibres become spontaneous when damaged. This is likely related with spontaneous pain in human patients. It is of interest that the spontaneous fibres present different temporal patterns, and that different ion channels shape these rhythms
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Why is it important?
The study of the temporal patterns of discharge in primary afferents has never been explored in detail, but it is of relevance to understand neural coding.
Perspectives
It is likely that spontaneous temporal patterns described in the nervous system share the same characteristics.
Dr Carolina Roza
University of Alcala
Read the Original
This page is a summary of: Hyperpolarization-activated channels shape temporal patterns of ectopic spontaneous discharge in C-nociceptors after peripheral nerve injury, European Journal of Pain, April 2018, Wiley,
DOI: 10.1002/ejp.1226.
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