Regioselective Synthesis of 2 -Arylindoles via Palladium -Catalyzed

What is it about?

A versatile route has been developed for the synthesis of 2‐arylindoles using a Pd‐catalyzed tandem process. Under reductive conditions, different 2‐arylindoles were synthesized from phenylglyoxal and aniline. This synthetic methodology involves a tandem reaction of four steps with high regioselectivity. Alternatively, 2‐anilinoacetophenones intermediates also can be using to give access to the corresponding 2‐arylindoles.

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Why is it important?

we report a synthesis of 2-arylindoles with high regioselectivity and good yields through a sequential condensat ion/reductive amination using a palladium catalyst under reductive conditions.