2-Hydroxypyridinyl-Substituted-Oxadiazoles and -Triazoles
What is it about?
A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones and their transformation into 1,2,4-oxadiazoles and 1,2,4-triazoles is presented. We also present the discovery of a new, rapid, and complementary access to 2-substituted 4H-benzo[e][1,3]oxazinones. Finally, the one-step transformation of some of these pyrido-oxazinones into the corresponding hydroxypyridyl-substituted 1,2,4-oxadiazoles and 1,2,4-triazoles was explored,
Why is it important?
We report in this publication the preparation of original aromatic heterocycles that could constitute new scaffolds for medicinal chemists.
The following have contributed to this page: Professor Serge THORIMBERT
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