Preparation of Halogen-Containing 4H-Pyrido[e][1,3]oxazin-4-ones and Their Transformation into 2-Hydroxypyridinyl-Substituted 1,2,4-Oxadiazoles and 1,2,4-Triazoles

Laetitia Le Falher, Omar Ben Ayad, Ozge Ziyaret, Candice Botuha, Serge Thorimbert, Franck Slowinski
  • European Journal of Organic Chemistry, May 2015, Wiley
  • DOI: 10.1002/ejoc.201500277

2-Hydroxypyridinyl-Substituted-Oxadiazoles and -Triazoles

What is it about?

A complete study on the preparation of original halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones and their transformation into 1,2,4-oxadiazoles and 1,2,4-triazoles is presented. We also present the discovery of a new, rapid, and complementary access to 2-substituted 4H-benzo[e][1,3]oxazinones. Finally, the one-step transformation of some of these pyrido-oxazinones into the corresponding hydroxypyridyl-substituted 1,2,4-oxadiazoles and 1,2,4-triazoles was explored,

Why is it important?

We report in this publication the preparation of original aromatic heterocycles that could constitute new scaffolds for medicinal chemists.

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The following have contributed to this page: Professor Serge THORIMBERT