Simple Porphyrin Desymmetrization: 5,10,15,20-Tetrakis(3-hydroxyphenyl)porphyrin (mTHPP) as a Gateway Molecule for Peripheral Functionalization

  • Simple Porphyrin Desymmetrization
  • Luke Rogers, Emeralda Burke-Murphy, Mathias O. Senge
  • European Journal of Organic Chemistry, May 2014, Wiley
  • DOI: 10.1002/ejoc.201402433

What is it about?

Porphyrins are often used in photodynamic cancer therapy. However, the synthesis of new drug candidates is often laborious. Here we describe a simple method how a known lead compound (mTHPP) can quickly be converted into new molecules using simple chemistry. The new protocols can also be used to prepare porphyrins with different residues for other applications which require unsymmetrical systems.

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http://dx.doi.org/10.1002/ejoc.201402433

The following have contributed to this page: Professor Mathias O. Senge