Cyclic dinucleotides modulate human T-cell response through monocyte cell death

What is it about?

Cyclic dinucleotides, a class of microbial messengers, have been recently identified in bacteria, but their activity in humans remains largely unknown. Here, we have studied the function of cyclic dinucleotides in humans. We found that c-di-AMP and cGAMP, two adenosine-based cyclic dinucleotides, activated immune cells in an unusual manner.

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