What is it about?
The review provides an overview of the adaptor proteins involved in the intracellular signaling cascades by which LFA-1 regulates T-cell motility and immune responses.
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Why is it important?
We review the role of the adaptor proteins in T-cell migration.
Perspectives
The complexity of the LFA-1-associated signaling delineated in this review suggests that it may be an important and challenging focus for future research, enabling the identification of “tunable” targets for the development of immunotherapies
Navin Kumar Verma
Nanyang Technological University
Read the Original
This page is a summary of: Adaptor regulation of LFA-1 signaling in T lymphocyte migration: Potential druggable targets for immunotherapies?, European Journal of Immunology, October 2014, Wiley,
DOI: 10.1002/eji.201344428.
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