Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances

What is it about?

this article explains the history behind the development of neprilysin inhibitors as a new treatment for heart failure - with final success with sacubitril/valsartan

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Why is it important?

neprilysin inhibition has been the most recent breakthrough in the treatment of heart failure and the first new treatment (sacubitril/valsartan) in 15 years to reduce mortality in this condition