Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer

“

This study is an important step to understand how aspirin works in the prevention of adenoma and carcinoma in the colon. It was difficult to understand how tiny amounts of aspirin that are just minutes in the blood system could affect colonic tissues and have such a big impact on colorectal cancer. We have shown that altough the impact on colonic epitelial cell COX-1 acetylation is lower than that observed in platelets, it seems sufficient to be persistent, decrease mucosal prostaglandin concentration and other key biological mediators of carcinogenesis.

”