What is it about?
The samples analyzed were from 1971-1976 when Fine Needle Aspiration Biopsy (FNAB) was the only method in practice and another sample from 1991 to 1995 when Cor Needle Biopsy (CNB) was introduced from 1989. The samples were optimal matched. Analyzing the accumulating numbers of distant metastases 5 to15 years after diagnosis resulted in a significant higher lever of distant metastases when CNBs were used as compared to FNABs.
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Why is it important?
The results do really make sense. Diagnostic methods should not make the patients survival worse in the long run. Postoperative hormon treatment have recently been suggested to be prolonged at out institution due to late coming metastases before our data became published. Further investigations have to be done and confirm or contradict our study.
Perspectives
CNB causes a much higher energy when the needle penetrates the needle truck and results in a stronger reaction of inflammation acting as a driving force towards tumor progression and spred of tumor cells into the blood vessels for further transport into the body. It will also be a resistance to accept such an information after many years of practicing CNB, which has offered a better method for diagnosis as compared to FNAB. It will take time to change a winning routine.
Roland Sennerstam
Department of Pathology and Oncology, Karolinska University Hospital and Karolinska Institutet, Stockholm Sweden
Read the Original
This page is a summary of: Reply to Imaging modalities for the detection of distant metastases in breast cancer patients diagnosed in the 1970s and 1990s: Does it make any sense?, Cancer Cytopathology, November 2017, Wiley,
DOI: 10.1002/cncy.21924.
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