What is it about?
Brief review of our work (1995 onward) on arene interactions (parallel mode) based on pyrazolo[3,4-d]pyrimidines and related heterocycles using flexible linkers like propylene, ethylene and butylidene. Most of these compounds show folded conformations.
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Why is it important?
Our work demonstrates that simple 1,3-diaryl-alkanes can exist in folded conformation both in solution and solid due mainly to arene interactions. Even 1,2-diaryl-alkanes can exist in folded conformation both in solution and solid due mainly to arene interactions.
Perspectives
Simplest possible models for understanding of arene interactions found in DNA and drug-receptor complexes.
kamlakar avasthi
Central Drug Research Institute
Read the Original
This page is a summary of: ChemInform Abstract: Arene—Arene Interactions and Application of Unimolecular Models for Their Understanding, ChemInform, May 2013, Wiley,
DOI: 10.1002/chin.201321273.
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