What is it about?
Triols (I) and (V) are subjected to fluoroalkylation by using racemic epoxides (II) in the presence of a strong Lewis acid to give, after deprotection, the amphiphiles (IV) and (VII) as new surfactants. In addition, the regioselectivity of the fluoroalkylation of two diols by epoxide (IIb) is investigated and appears to be considerably dependent on the catalyst used. The new amphiphiles (IV) and (VII) reveal excellent co-emulsifying properties and have very good to excellent hemocompatibility.
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Why is it important?
Triols (I) and (V) are subjected to fluoroalkylation by using racemic epoxides (II) in the presence of a strong Lewis acid to give, after deprotection, the amphiphiles (IV) and (VII) as new surfactants. In addition, the regioselectivity of the fluoroalkylation of two diols by epoxide (IIb) is investigated and appears to be considerably dependent on the catalyst used. The new amphiphiles (IV) and (VII) reveal excellent co-emulsifying properties and have very good to excellent hemocompatibility.
Perspectives
Triols (I) and (V) are subjected to fluoroalkylation by using racemic epoxides (II) in the presence of a strong Lewis acid to give, after deprotection, the amphiphiles (IV) and (VII) as new surfactants. In addition, the regioselectivity of the fluoroalkylation of two diols by epoxide (IIb) is investigated and appears to be considerably dependent on the catalyst used. The new amphiphiles (IV) and (VII) reveal excellent co-emulsifying properties and have very good to excellent hemocompatibility.
Dr Vladimír Církva
Institute of Chemical Process Fundamentals
Read the Original
This page is a summary of: Amphiphilic Perfluoroalkylated Derivatives of Aliphatic Triols: Hemocompatibility and Effect on Perfluorocarbon Emulsion., ChemInform, March 2003, Wiley,
DOI: 10.1002/chin.200314072.
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