Synthesis of Fluorinated Heterocycles.

What is it about?

This article describes the preparation of new heterocyclic aromatic molecules such as pyrazoles, quinolines, isoxazoles and pyrimidines using fluorinated 1,3-diketones. This paper shows that the 1,3-diketone scaffold is a valuable means of introducing fluorine in a selective way in the building of aromatic heterocycles.

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Why is it important?

Fluorinated heterocycles make up an important class of compounds with pharmaceutical and agrochemical properties. Many of the target molecules in this paper are potential pharmcophores.