ChemInform Abstract: Synthesis of 1‐Aminocyclopropanol by Anodic Oxidation.

What is it about?

The decarboxylation of 2-(tert-butoxycarbonylamino)isobutyric acid by anodic oxidation in methanol or ethanol gives the corresponding tert-butyl N-(1-alkoxy-1-methylethyl)carbamates. The decarboxylation of 1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid offers a new and efficient synthesis of tert-butyl N-(1-ethoxycyclopropyl)carbamate. Hydrolysis with acid yields the hydrochloride of 1-aminocyclopropanol, a potent enzyme inhibitor.

Featured Image