Designing a Red‐Emitting Viscosity‐Sensitive BODIPY Fluorophore for Intracellular Viscosity Imaging

What is it about?

Here we describe how we developed a new red emitting, viscosity-sensitive, BODIPY fluorophore BP-PH-2MNO2 that is suitable for reliable intracellular viscosity imaging of lipid droplets in MCF-7 breast cancer cells. The design of BP-PH-2M-NO2 was aided by DFT calculations that allowed a successful prediction of the viscosity sensitivity of fluorophores before synthesis.

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Why is it important?

we report a new red viscosity probe possessing monoexponential fluorescence decay that makes it attractive for lifetime-based viscosity imaging.