What is it about?

An α1-Dawson polyanion bearing a lateral side chain with a 4-aminopyridine end group was synthesized. This organo-POM catalyzes the addition of indenyl allyl silanes to cinnamoyl fluorides. The polyanionic framework influences the organocatalyst activity and selectivity. A moderate but nonzero chirality transfer from the chiral inorganic framework to the organic substrate was observed.

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Why is it important?

The first chirality transfer from oxide surface of chiral POM to organic compounds.

Perspectives

Better enantioselectivities should be report in the future. Chiral POMs are a wonderful class of inorganic compounds.

Professor Serge THORIMBERT
Sorbonne Université

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This page is a summary of: Intramolecular Anion Effect in Polyoxometalate-Based Organocatalysts: Reactivity Enhancement and Chirality Transfer by a Metal Oxide-Organic Cation Interaction, Chemistry - A European Journal, October 2014, Wiley, DOI: 10.1002/chem.201403989.
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