Intramolecular Anion Effect in Polyoxometalate-Based Organocatalysts: Reactivity Enhancement and Chirality Transfer by a Metal Oxide-Organic Cation Interaction

Christian Brazel, Nathalie Dupré, Max Malacria, Bernold Hasenknopf, Emmanuel Lacôte, Serge Thorimbert
  • Chemistry - A European Journal, October 2014, Wiley
  • DOI: 10.1002/chem.201403989

chiral POM as original organocatalysts

What is it about?

An α1-Dawson polyanion bearing a lateral side chain with a 4-aminopyridine end group was synthesized. This organo-POM catalyzes the addition of indenyl allyl silanes to cinnamoyl fluorides. The polyanionic framework influences the organocatalyst activity and selectivity. A moderate but nonzero chirality transfer from the chiral inorganic framework to the organic substrate was observed.

Why is it important?

The first chirality transfer from oxide surface of chiral POM to organic compounds.

Perspectives

Professor Serge THORIMBERT
Sorbonne Université

Better enantioselectivities should be report in the future. Chiral POMs are a wonderful class of inorganic compounds.

Read Publication

http://dx.doi.org/10.1002/chem.201403989

The following have contributed to this page: Professor Bernold Hasenknopf and Professor Serge THORIMBERT