What is it about?
High-dose- rate interstitial brachytherapy may provide durable local control with acceptable cosmetic outcomes in carefully selected patients with xeroderma pigmentosum and cutaneous squamous cell carcinoma. This long-term follow-up case questions the absolute contraindication of radiotherapy in XP and underscores the importance of individualized treatment planning based on underlying DNA repair mechanisms.
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Why is it important?
This Study Presents an Eight-Year Follow-Up Case Report
Perspectives
This case supports the potential role of HDR interstitial BT as a safe and effective treatment for selected XP patients with localized skin SCC. While our findings suggest that XP-related UV hypersensitivity may not necessarily translate to ionizing radiation intolerance, further multicenter data are needed before altering established contraindications. This report emphasizes the need for individualized treatment planning and cautious optimism when applying RT in genetic hypersensitivity syndromes.
Dr. Pouya Saraei
Shiraz University of Medical Sciences
Read the Original
This page is a summary of: Successful Interstitial
HDR
Brachytherapy for Nasal Skin
SCC
in Xeroderma Pigmentosum: An Eight‐Year Follow‐Up Case Report, Clinical Case Reports, April 2026, Wiley,
DOI: 10.1002/ccr3.72516.
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