What is it about?

Label‐free biosensors offer accurate sensing capabilities due to reliable quantification of biological and biochemical processes. These devices function by establishing a dynamic interaction of analyte and receptor molecules and convert it into a measurable signal through a transducer.

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Why is it important?

Over the past decades, label‐free biosensors have attracted attention in biomedical applications due to the ease of linking nanomaterials with bioreceptor molecules. In this review, recent advances in sensitivity, specificity, and sensing mechanism related to label‐free biosensors of metallic nanoparticles (MNPs) of gold (AuNP), silver (AgNP), aluminum (AlNP), copper (CuNP), and zinc oxide (ZnONP) are presented. Selected sensing methods based on fluorescence, surface plasmon resonance (SPR), surface‐enhanced Raman spectroscopy (SERS), metal‐enhanced fluorescence (MEF), and electrochemical sensor are discussed.


New measurement techniques and rapid progress of label‐free biosensor are going to play a vital role in real‐time detection of biomarkers in clinical samples, such as blood plasma, serum, and urine as well as in targeted drug delivery. Future trend of these label‐free bio‐sensing mechanisms and their development are also discussed.

Dr. Sitansu Sekhar Nanda
Myongji University

Read the Original

This page is a summary of: Strategies for Development of Metallic Nanoparticle‐Based Label‐Free Biosensors and Their Biomedical Applications, ChemBioChem, October 2019, Wiley,
DOI: 10.1002/cbic.201900566.
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