What is it about?
This study provided the first evidence that high CD73 expression associated with high TGF- production by cervical cancer cells cultured as tumorspheres strongly contributes to the induction of protumoral characteristics related to tumor progression, such as migration and invasiveness, immune evasion, immunosuppression, and chemoresistance.
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Photo by National Cancer Institute on Unsplash
Why is it important?
The presence of the TGF-b-CD73–Adenosine feedback loop can promote protumoral characteristics in the cervical cancer tumor microenvironment.
Perspectives
The protumoral role of the TGF-b-CD73–Adenosine feedback loop in cervical cancer microenvironment has clinical importance as a therapeutic target
ALBERTO MONROY-GARCIA
Universidad Nacional Autonoma de Mexico
Read the Original
This page is a summary of: Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF‐β production, Cell Biochemistry and Function, September 2022, Wiley,
DOI: 10.1002/cbf.3742.
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