DNA methylation dynamics in plants and mammals: overview of regulation and dysregulation

What is it about?

This review discusses the regulation and dysregulation of DNA methylation in plants and mammals.

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Why is it important?

DNA methylation dynamics are regulated by three processes de novo DNA methylation, methylation maintenance and DNA demethylation. These processes have their similarities and differences between mammals and plants. Furthermore, the dysregulation of DNA methylation dynamics represents one of the primary molecular mechanisms of developing diseases in mammals.