What is it about?
HMGA2 promotes the gene expression of MMP2, a secretory proteinase which could digest the matrix of tumor cells and induce cell invasion.
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Why is it important?
We found a noval function of HMGA2, by recruit GCN5 to promter of MMP2, HMGA2 induces the chromatin region of MMP2 promters folding with each other and induces MMP2 transcription.
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This page is a summary of: HMGA2 promotes glioma invasion and poor prognosis via a long-range chromatin interaction, Cancer Medicine, May 2018, Wiley,
DOI: 10.1002/cam4.1534.
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