What is it about?
Tiny blood drop is good enough to enough find out apalutamide concentration using drie blood spot card and mass spetrometer. Very useful for cancer patients therapeutic drug monitoring.
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Why is it important?
Hassle free sample processing, easy to store and transport. Droplet of blood is enough and it is less invasive compare to conventional blood collection. Very useful for elderly patients in clinical set up.
Perspectives
Though DBS is a robust technique but needs regulatory approval to be used as a routine tool. DBS approach need to be implemented end-to-end in drug discovery process for its validity and utility.
Dr Ramesh Mullangi
Jubilant Biosys Ltd
Read the Original
This page is a summary of: A novel dried blood spot LC-MS/MS method for the quantification of apalutamide in mouse whole blood: Application to pharmacokinetic study in mice, Biomedical Chromatography, August 2018, Wiley,
DOI: 10.1002/bmc.4344.
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