Quantification of amlodipine and atorvastatin in human plasma by UPLC-MS/MS method and its application to a bioequivalence study

What is it about?

Novel sample preparation for basic and acidic drugs. Two steps of sample preparation are utilized to extract both analytes in a stepwise manner. This novel procedure could be applied for similar drug moities.

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Why is it important?

Extraction of an acidic and a basic drug from plasma could be done in a two-step sample preparation. Based on how to make the analyte extractable in organic solvents by modifying its ionization state is an art of sample preparation.