What is it about?
Expression vector that contains reverse complementary sequences may have an undesirable DNA recombination that leads to mutations.
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Why is it important?
Identifying mutations early can significantly save time down the road.
Perspectives
To ensure biologics quality and bring innovative medicines to patients faster.
Dr Yueming Qian
Bristol-Myers Squibb Co
Read the Original
This page is a summary of: Early identification of unusually clustered mutations and root causes in therapeutic antibody development, Biotechnology and Bioengineering, June 2018, Wiley,
DOI: 10.1002/bit.26728.
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