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In this work, we propose an alternative dynamic metabolic flux analysis based on convex analysis, DMFCA, which is suitable for underdetermined systems. This approach allows the determination of bounded intervals for the fluxes using the available knowledge of the metabolic network and information provided by the time evolution of extracellular component concentrations. The main advantage of the proposed procedure is that it does not require additional constraints or objective functions, and provides relatively narrow intervals for the intracellular metabolic fluxes.

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This page is a summary of: Dynamic metabolic flux analysis using a convex analysis approach: Application to hybridoma cell cultures in perfusion, Biotechnology and Bioengineering, December 2015, Wiley,
DOI: 10.1002/bit.25879.
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