What is it about?
By introducing thiamine regulation strategy, thiamine-deficient mutants were selected, and the relationship between thiamine content and cell quantitative accumulation was analyzed. Finally, the efficient synthesis of D-lactic acid under orderly control of cell growth was realized.
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Why is it important?
The contradiction between product synthesis and cell proliferation has been effectively solved, which enables highly active cells to exert the catalytic properties of immobilized enzymes in a special way, thus achieving high speed and high conversion of catalytic process.
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This page is a summary of: Limitation of thiamine pyrophosphate supply to growingEscherichia coliswitches metabolism to efficientd-lactate formation, Biotechnology and Bioengineering, August 2015, Wiley,
DOI: 10.1002/bit.25699.
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