Astin C production by the endophytic fungus Cyanodermella asteris in planktonic and immobilized culture conditions

Antoine Vassaux, Cédric Tarayre, Anthony Arguëlles‐Arias, Philippe Compère, Frank Delvigne, Patrick Fickers, Linda Jahn, Alexander Lang, Valérie Leclère, Jutta Ludwig‐Müller, Marc Ongena, Thomas Schafhauser, Samuel Telek, Ariane Théatre, Willem J.H. Berkel, Micheline Vandenbol, Karl‐Heinz Pée, Luc Willems, Wolfgang Wohlleben, Philippe Jacques
  • Biotechnology Journal, June 2019, Wiley
  • DOI: 10.1002/biot.201800624

Astin C production by the endophytic fungus Cyanodermella asteris

What is it about?

This work describes the scale up of the production of astin C by the fungal endophyte Cyanodermella asteris.

Why is it important?

Cyanodermella asteris is a fungal endophyte recently isolated from the medicinal plant Aster tataricus. C.asteris produces astin C, a cyclic pentapeptide with anticancer and anti-inflammatory properties. In this work we show that the production of astin C can be improved by using immobilized cell culture conditions.

Perspectives

Professor Willem J.H. van Berkel
Wageningen University

The immobilized cell-culture conditions improve the production of astin C and enable a facilitate recovery and purification of the secondary metabolite. For future large scale production, the exclusive growth on the support will result in a significant decrease of downstream processing costs.

Read Publication

http://dx.doi.org/10.1002/biot.201800624

The following have contributed to this page: Professor Willem J.H. van Berkel