What is it about?
Inflammation and oxidative stress conditions lead to a variety of oxidativemodifications of lipoprotein phospholipids implicated in the occurrence anddevelopment of atherosclerotic lesions. Lipoprotein-associated phospholipaseA2 (Lp-PLA2) is established as an independent risk biomarker ofatherosclerosis-related cardiovascular disease (ASCVD) and mediates vascularinflammation through the regulation of lipid metabolism in the blood and inatherosclerotic lesions. Lp-PLA2is associated with low- and high-density lipo-proteins and Lipoprotein (a) in human plasma and specifically hydrolyzes oxi-dized phospholipids involved in oxidative stress modification. Several oxidizedphospholipids (OxPLs) subspecies can be detoxified through enzymatic degra-dation by Lp-PLA2activation, forming lysophospholipids and oxidized non-esterified fatty acids (OxNEFAs). Lysophospholipids promote the expression ofadhesion molecules, stimulate cytokines production (TNF-α, IL-6), and attractmacrophages to the arterial intima.
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Why is it important?
The present review article discusses newdata on the functional roles of OxPLs and Lp-PLA2associated withlipoproteins.
Perspectives
The investigation of OxPLs in ASCVDs
Dr DESPOINA PANTAZI
University of Ioannina, Greece
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” Oxidized phospholipids and lipoprotein‐associated phospholipase
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..., BioFactors, October 2022, Wiley,
DOI: 10.1002/biof.1890.
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