What is it about?
The present study aimed to investigate the role of microRNA‐146a and its adapter proteins [interleukin‐1 receptor‐associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor‐associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)‐sensitized rats in association with the diet‐induced obesity condition.
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Why is it important?
These results suggest that a defect in the NF‐kB–miR‐146a negative feedback loop may be involved in the pathogenesis of obesity associated with OVA‐sensitized condition.
Perspectives
I hope this article will help you understand the possible pathways of the relationship between asthma and obesity. Based on previous studies, asthma has been shown to be associated with obesity, but no possible mechanisms have been identified.
Dr Mohammad Reza Aslani
Ardabil University of Medical Sciencese
Read the Original
This page is a summary of: Effect of high fat diet on NF-кB microRNA146a negative feedback loop in ovalbumin-sensitized rats, BioFactors, December 2018, Wiley,
DOI: 10.1002/biof.1466.
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