Nonlinear Dispersive Model of Electroporation for Irregular Nucleated Cells

What is it about?

This paper reports a nonlinear, non‐local, dispersive, and space–time multiphysics model for studying the electroporation phenomenon in irregular nucleated cells. It make possible a detailed evaluation of the cell response induced by pulsed electric field in terms of transmembrane voltages and pore densities.

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Why is it important?

The developed numerical algorithm overcomes the main computational difficulties which numerical models available in the literature suffers from. More precisely, the main drawbacks concerning the thinness of the membrane, the high contrast between the electric properties of the cytoplasm and the cell membrane, and in the different time-domain dielectric response of the cell compartments have been successfully solved.