What is it about?

The study investigates the relationship between low carbohydrate diet (LCD) scores and bladder cancer risk using data from the Singapore Chinese Health Study, which included 63,275 participants. Over a follow-up of 17.6 years, 250 cases of bladder cancer were identified. Results indicated a significant positive association between animal-based LCD scores and bladder cancer risk, while plant-based LCD scores showed no significant association. The study suggests that diets high in animal-derived fats and proteins may increase bladder cancer risk, highlighting the potential for dietary modifications in bladder cancer prevention programs. The findings underscore the importance of considering dietary factors, alongside smoking, in understanding bladder cancer etiology.

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Why is it important?

This research is important as it explores the association between low-carbohydrate diets (LCD) and the risk of bladder cancer, focusing on the source of macronutrients—animal-based versus plant-based. Understanding the dietary factors that may influence bladder cancer risk is crucial for developing effective prevention and control strategies. The study highlights how animal-based LCDs may increase the risk of bladder cancer, which can inform dietary recommendations and public health policies aimed at reducing the incidence of this malignancy. With bladder cancer being a common and serious health concern, identifying modifiable risk factors such as diet is essential for improving public health outcomes. Key Takeaways: 1. Animal-Based LCD Risk: The study found a statistically significant positive association between animal-based LCD scores and increased risk of bladder cancer, suggesting that diets high in animal-derived fats and proteins may elevate cancer risk. 2. Plant-Based LCD Neutrality: In contrast, the research indicated no significant association between plant-based LCD scores and bladder cancer risk, implying that plant-derived fats and proteins might be safer regarding bladder cancer. 3. Public Health Implications: These findings emphasize the importance of considering the source of macronutrients in dietary guidelines and cancer prevention programs, potentially steering individuals towards plant-based diets to reduce bladder cancer risk.

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This page is a summary of: Low‐carbohydrate diet score and risk of bladder cancer: Findings from a prospective cohort study, BJUI Compass, June 2025, Wiley,
DOI: 10.1002/bco2.70033.
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