Cribriform pattern in prostate biopsy: Predictor for aggressive prostate cancer after surgery

What is it about?

This study aimed to investigate the relationship between a cribriform pattern on prostate biopsy and suspicion of intraductal carcinoma of the prostate (IDC-P) after radical prostatectomy. A total of 100 men who underwent prostatectomy from 2015 to 2019 were assessed. The cribriform pattern was evaluated with hematoxylin and eosin counterstaining, and IDC-P was evaluated with immunohistochemical analysis of cytokeratin 34βE12. Results showed that patients with IDC-P confirmed in biopsy tissue were an independent predictor of biochemical recurrence after prostatectomy. The rate of IDC-P confirmation was 28% of cases with a cribriform pattern in biopsy tissue, which increased to 62% in prostatectomy tissues. The cribriform pattern may predict IDC-P, and evaluation for IDC-P in biopsy tissue may be useful to consider when deciding treatment policies for this patient population.

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Why is it important?

This research is important because it investigates the relationship between the cribriform pattern on prostate biopsy and the suspicion of intraductal carcinoma of the prostate (IDC-P) after radical prostatectomy. It highlights the potential of using the cribriform pattern as a predictor for IDC-P, which can aid in decision-making for treatment strategies. Key Takeaways: 1. The cribriform pattern may predict IDC-P, which is an aggressive form of prostate cancer. 2. Evaluation for IDC-P in biopsy tissue may be useful in deciding the treatment policy for patients with the cribriform pattern. 3. The cribriform pattern in biopsy tissue was not associated with biochemical recurrence, but its presence in postoperative tissues was related to biochemical recurrence. 4. The study suggests that the cribriform pattern may be a predictor for IDC-P, which may be associated with genomic instability and DNA repair gene mutations.