What is it about?
The chemical behavior of S-glycopyranosyl-N-monoalkyl dithiocarbamates (DTCs) as masked 1-glycosyl thiols, easily prepared by the nucleophilic displacement of 1-halo sugars with dithiocarbamate salts of primary amines, has been studied and synthetically exploited.
Why is it important?
Our finding have been applied for the preparation of thioglycosyl vinyl sulfones, thiodisaccharides, and S-linked homo- and heterodivalent neoglycoconjugates are described as a proof-of-concept of the great potential of the sugar DTCs in any chemical scenario in which the covalent attachment of a thiol sugar is required.
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This page is a summary of: Masked Thiol Sugars: Chemical Behavior and Synthetic Applications ofS-Glycopyranosyl-N-monoalkyl Dithiocarbamates, Chemistry - An Asian Journal, November 2013, Wiley, DOI: 10.1002/asia.201301270.
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