What is it about?
IgG4-related disease is new disease entity characterized by unknown mechanisms. We showed that follicular helper 2 T cells (Tfh2) play an important role with linkage to increased serum levels of IgG4, interleukin-4, and increased numbers of plasmablasts.
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Why is it important?
The role of follicular helper 2 T cells in the pathogenesis of IgG4-related disease has not been reported until we have showed in this article.
Perspectives
To elucidate the molecular mechanism of increased follicular helper 2 T cells will lead to the new therapheutic target in IgG4-related disease!
Dr Mitsuhiro Akiyama
Keio University School of Medicine
Read the Original
This page is a summary of: Brief Report: Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin-4 Levels and Plasmablast Numbers in IgG4-Related Disease, Arthritis & Rheumatology, August 2015, Wiley,
DOI: 10.1002/art.39209.
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