What is it about?
Little is understood how osteoarthritis of the knee begins. For a Long time it was considered to be a cartilage-only problem with subsequent progressive loss of further cartilage. We could show that osteoarthritis may start affecting different joint tissues including cartilage, but also the bone, meniscus or the synovium.
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Why is it important?
In the long run we hope that targeting the different Joint tissues involved in the disease Initiation process may delay or prevent the onset of knee osteoarthritis.
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This page is a summary of: What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging-Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative, Arthritis & Rheumatology, May 2015, Wiley,
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