What is it about?
Controlling protein adsorption on solid surfaces is important in biomedical applications. Polymer surface properties have synergestic effects on protein adsorption. For polyurethanes, we have shown the net effect of various surface properties on serum albumin adsorption. We have used both experimental techniques and molecular simulations.
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Why is it important?
There are conflicting results in literature which polyurethane surface property is promoting or preventing protein adsorption. With this integrative study, we showed that a) crystallinity promotes albumin adsorption, b) roughness together with topological features of the surface cam promote or prevent adsorption, c) microphase separation in polyurethanes has an impact on albumin adsorption.
Perspectives
I think this study sets a very good example of how we can employ both molecular simulations and polymer characterization techniques such as AFM to explain this very complicated phenomena.
Ozge Kurkcuoglu
Istanbul Teknik Universitesi
Read the Original
This page is a summary of: A multiscale investigation on controlling bovine serum albumin adsorption onto polyurethane films, Journal of Applied Polymer Science, August 2017, Wiley,
DOI: 10.1002/app.45669.
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