What is it about?
Sulfate is an important anion in biological systems. We have shown for the first time that small molecules can bind to sulfate, azomethine group. Interestingly pyridene attached NH2 group not involved in the coordination and based on this after complexation compared with ligand complexes showed potent activity.
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Why is it important?
our findings show that the compounds showed good cytotoxicity against the tumor cancer cell lines and well correlate with docking studies, structure of the compounds confirmed by single crystal X-ray diffraction and DFT studies were also done.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.
Laxmareddy Kotha
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This page is a summary of: Synthesis, Structural, Biological Evaluation, Molecular Docking and DFT Studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) Complexes bearing Heterocyclic Thiosemicarbazone ligand, Applied Organometallic Chemistry, May 2018, Wiley,
DOI: 10.1002/aoc.4415.
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