What is it about?
Amprolium is a chemical analogue of thiamine, antagonizing its effects and causing vitamin deficiency. Thus, amprolium is potentially useful for use as a study model of thiamine deficiency. We tested its effects on mice on the behavioral, metabolic and anatomopathological aspects.
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Why is it important?
This study demonstrates the potentials of amprolium in inducing neurological and metabolic changes in mice. Interestingly, these effects also appear to be mediated by oxidative stress and inflammation, similar to the known pyrithiamine. However, the effects produced by amprolium are more lenient, and they emerge progressively, which makes possible the detailed evaluation of the organic changes.
Perspectives
With these new discoveries, we have opened up great prospects for future studies. Many biological aspects, including cellular mechanisms involved in the changes induced by amprolium, could be investigated soon with this new model of induction of thiamine deficiency.
Dr Fabiano Mendes de Cordova
Universidade Federal do Norte do Tocantins
Read the Original
This page is a summary of: Amprolium exposure alters mice behavior and metabolism in vivo, Animal Models and Experimental Medicine, November 2018, Wiley,
DOI: 10.1002/ame2.12040.
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