What is it about?

Benzoxadiazepines have been reported to bring valuable medical and industrial benefits. Nonetheless, there are not many remarkable published studies on the synthesis of benzoxadiazepines. To be more specific, the rare seven-member benzo-1,3,4-oxadiazepine is known to be a biologically active compound. Hence, this research focuses on the synthesis of this rare compound via simple steps. In the study, the effects of different reaction conditions, substituent and mixing protocols on the synthesis were examined. As a result, a series of benzo-1,3,4-oxadiazepine derivatives were successfully prepared with a yield of 83 % via a set of facile procedures.

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Why is it important?

Benzoxadiazepines are gaining attention for their significant activities as antibacterial, muscle relaxant, stimulant to the central nervous system, tranquilizer, anticonvulsant, and pesticides. The full potential of this compound to human’s well-being is yet to be fully understood. In order to contribute to the continuity of such studies, the synthesis of benzo-1,3,4-oxadiazepine has been established. The reported synthesis method can achieve a yield of 83 %. Such high efficiency in the synthesis is vital in facilitating scientists in the exploration of the real potential of benzoxadiazepines..


This study aims to achieve “Goal 3: Good Health and Well-being” of the UN’s Sustainable Development Goals (SDG). The outcome of the research proves the ease with which this rare compound could be synthesized and transformed into various derivatives. Further exploration of the biological potentials of these compounds, such as anti-viral and anti-cancer properties, would indeed primarily benefit the medical industries to improve the quality of life.

Yean Kee Lee
University of Malaya

Read the Original

This page is a summary of: Facile Intramolecular Cyclization ofN-(2-Hydroxybenzoyl)hydrazones toN,N′-Diacetyl Benzo-1,3,4-oxadiazepine Derivatives, Asian Journal of Organic Chemistry, February 2018, Wiley, DOI: 10.1002/ajoc.201800014.
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