Synthesis of Substituted Quinolines by Iron(III)-Catalyzed Three-Component Coupling Reaction of Aldehydes, Amines, and Styrenes

  • Parthasarathy Gandeepan, P. Rajamalli, Chien-Hong Cheng
  • Asian Journal of Organic Chemistry, February 2014, Wiley
  • DOI: 10.1002/ajoc.201300262

Quinoline Synthesis

What is it about?

An easy way to synthesis of substituted quinolines is described. Simple reaction of aldehyde, amine and styrenes in the presence of iron(III) chloride afford quinolines in high yields.

Why is it important?

The method is very simple and proceeds with easily available starting materials.

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The following have contributed to this page: Gandeepan Parthasarathy and Rajamalli P