Non-communicable disease

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Low birthweight is associated with a decreased risk of childhood leukaemia and an increased risk of both cardiovascular disease and all-cause mortality in adult life. Possible biological mediators include systemic innate immunity and inflammation. We tested the hypothesis that serum highly sensitive C Reactive Protein (hsCRP), a measure of both innate immunity and systemic inflammation, was positively associated with decreased birthweight. These observations provide a potential mechanism that is present at the age of three years old for the association between low birthweight and both decreased childhood leukaemia and increased cardiovascular disease in adults.

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