What is it about?
This review points out the excellent suitability of the Cu-catalyzed alkyne-azide cycloaddition for creating novel one-pot methodologies in the sense of multi-component reactions (MCR). In particular, the facile introduction of 1,2,3-triazole in combination with the diversity-oriented aspect of MCR allows for a rapid access to functional and structural space in all kinds of molecular sciences.
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Why is it important?
Creating structural diversity with a minimum of synthetic operation is the key to leadfinding in pharma, agrochemicals, catalyst research and even functional materials. Novel one-pot methodologies are conceptually superior to classical two component transformations.
Perspectives
Our group constantly applies Cu-catalyzed alkyne-azide cycloaddition for creating novel unprecedented concatenations with fundamental organic reactivity. From our out set we are particularly interested in accessing methodologies to prepare functional heterocycles for medicinal chemistry and for materials science. The latter field of research is also conducted by applying physical-organic principles to identify novel structure-property relationships.
Professor Thomas J J Müller
Heinrich-Heine-Universitat Dusseldorf
Read the Original
This page is a summary of: Multicomponent Syntheses based upon Copper-Catalyzed Alkyne-Azide Cycloaddition, Advanced Synthesis & Catalysis, February 2015, Wiley,
DOI: 10.1002/adsc.201400904.
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