What is it about?
Treatment of multiple brain metastases by radiotherapy can employ either a conventional multiple-isocenter (MI) or alternatively, a single- isocenter (SI) approach. SI approach provides simultaneous treatment for multiple lesions using the same setup of treatment and is able to shorten the overall treatment duration. The purposes of this study were to evaluate both approaches and compare the impacts of setup discrepancies within treatment duration on the robustness of respective approaches, whether the same magnitude of shifts could lead to a significant difference between the two approaches.
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Why is it important?
Single-isocenter (SI) approach used for radiotherapy treatment of multiple brain lesions is appreciated by its ability to result in similar target coverage and conformity to plans using multiple-isocenter (MI) approach, but with significantly shorter overall treatment duration. This study has demonstrated the effects of potential intra-fractional setup errors to both approaches, in which SI plans were relatively more vulnerable than MI plans in rotational shifts.
Perspectives
I hope this article would help people to look deeper into different techniques for stereotactic treatment of radiotherapy in clinical setting, which may not be as ideal as we thought. We may need to recognize the dosimetric outcomes of intra-fractional errors in daily patient treatment. Treating patients with a suitable approach is of paramount significance to be beneficial and reduce uncertainties. Accuracy and efficacy of treatment should be emphasised. I wish the study can pave the way for further researches in clinical consequence of the two approaches.
Sylvia Tsui
University of Hong Kong
Read the Original
This page is a summary of: Comparison of dosimetric impact of intra‐fractional setup discrepancy between multiple‐ and single‐isocenter approaches in linac‐based stereotactic radiotherapy of multiple brain metastases, Journal of Applied Clinical Medical Physics, December 2021, Wiley,
DOI: 10.1002/acm2.13484.
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