TERT Structure, Function, and Molecular Mechanisms

  • Emmanuel Skordalakes, Neal F. Lue
  • May 2012, Wiley
  • DOI: 10.1002/9781118268667.ch3

Structure function of telomerase and human disease

What is it about?

Structural and functional analysis of telomerase, the enzyme that replicates the ends of our chromosomes. Understanding the mechanism of action of naturally occurring TERT mutations in human disease.

Why is it important?

The study provides mechanistic insights into telomere replication by telomerase and sheds light into human disease associated with naturally occurring TERT mutations.

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The following have contributed to this page: Professor Emmanuel Skordalakes