The Potential of In Silico and In Vitro Approaches to Predict In Vivo Drug-Drug Interactions and ADMET/TOX Properties

  • Kenneth Bachmann, Sean Ekins
  • February 2012, Wiley
  • DOI: 10.1002/9781118230275.ch13

Predicting drug-drug interactions in vitro and in silico

What is it about?

This chapter describes in vitro-in vivo correlations and focuses on drug-drug interactions with CYPs, transporters and nucler receptors. In silico approaches are also described in this area.

Why is it important?

Suggests the importance of in vitro and in silico approaches as a combined effort to predict DDI. It has deep coverage of IVIVC.


Dr Sean Ekins
Collaborations in Chemistry

I have been honored to collaborate several times with Dr. Bachmann over the years as he has excellent knowledge of IVIVC. Although we put this together several years ago it covers areas still relevant today.

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The following have contributed to this page: Dr Sean Ekins