Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase)

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Why is it important?

S-adenosylmethionine is the main supplier of methyl groups for the dozens of methyltransferases that exist in cells. These process involved from the synthesis of small compounds (e.g. phospholipids, neutotransmitters, etc.) to epigenetic regulation (e.g. DNa and histone methylation). Thus, changes in the availability of S-adenosylmethionine have been related to many pathologies (e.g. liver disease, Alzheimer, etc.) and the available knowledge used to develop inhibitors/analogues.